From Hell is thoroughly-researched historical speculative fiction, and it's a tremendous work of art. Jack the Ripper has been studied to death in the literature, and there isn't much consensus about the identity of the murderer. Moore has taken a recent theory (one of the more plausible ones in many ways) and woven it into a complex story of conspiracy that oozes with period authenticity. The extensive end notes reveal the details of Moore's scholarship, and highlight the intensive research that Campbell put into the artwork as well.

All though it is a work of scholarship, this graphic novel is also brutally adult. There are extensive scenes of graphic violence and sex, some of which border on being gratuitous. It is also hard to follow in places, though the end notes help considerably, and many of the confusing scenes become clear in retrospect after finishing the work.

For me, this surpasses V for Vendetta and Watchmen, and therefore is likely Moore's greatest work.